钙离子调控的胞吐/胞吞机制研究及其动力学模型；

钙离子通道及突触传递对突触可塑性的调控；

基于MCELL的精细神经递质释放动力学模型。

Yichen Wu, Qingzhuo Liu, Bin Guo, Fangfei Ye, Jianlong Ge, and Lei Xue, BDNF activates postsynaptic TrkB receptors to induce endocannabinoid release and inhibit presynaptic calcium influx at a calyx-type synapse, Journal of Neuroscience, [2020], 40(42): 8070-8087.

Ying-ying Huang, Yu-qi Wang, Yi-ming Gao, Qing-zhuo Liu, Fang-fei Ye, Bin Guo, Yi-chen Wu and Lei Xue, BDNF and Its Multirole Function in Neurogenesis, Synaptic Transmission and Neurodegenerative Diseases, Nano LIFE, [2020], 10(1-2): 2040007.

Qing-Zhuo Liu, Mei Hao, Zi-Yang Zhou, Jian-Long Ge, Yi-Chen Wu, Ling-Ling Zhao, Xiang Wu, Yi Feng, Hong Gao, Shun Li* and Lei Xue*, Propofol reduces synaptic strength by inhibiting sodium and calcium channels at nerve terminals, Protein & Cell, [2019], 10(9): 688-693.

Bing Jia, Yichen Wu, Dan He, Baihong Guo, and Lei Xue*, Dynamics of transitions from anti-phase to multiple in-phase synchronizations in inhibitory coupled bursting neurons, Nonlinear Dynamics, [2018], 93(3): 1599-1618.

Bing Jia, Huaguang Gu* and Lei Xue, A basic bifurcation structure from bursting to spiking of injured nerve fibers in a two-dimensional parameter space, Cognitive Neurodynamics, [2017], 11(2): 189-200.

Kai Wang, Jun-Mei Lu, Zhen-He Xing, Qian-Ru Zhao, Lin-Qi Hu, Lei Xue, Jie Zhang, and Yan-Ai Mei, Effect of 1.8GHz radiofrequency electromagnetic radiation on novel object associative recognition memory in mice, Scientific Reports, [2017], 7(1): 44521.

Li Li, Hexige Saiyin, Jingmo Xie, Lixiang Ma, Lei Xue, Wei Wang, Weimin Liang, and Qiong Yu, Sevoflurane preconditioning induced endogenous neurogenesis against ischemic brain injury by promoting microglial activation, Oncotarget, [2017], 8(17): 28544-28557.

Jing Cui, Yi Ding, Shu Chen, Xiaoqiang Zhu, Yichen Wu, Mingliang Zhang, Yaxin Zhao, Tong-Ruei R. Li, Ling V. Sun, Shimin Zhao, Yuan Zhuang, Weiping Jia, Lei Xue, Min Han, Tian Xu and Xiaohui Wu, Disruption of Gpr45 causes reduced hypothalamic POMC expression and obesity, Journal of Clinical Investigation, [2016], 126(9): 3192-3206.

Zhi-cheng Sun, Jian-long Ge, Bin Guo, Jun Guo, Mei Hao, Yi-chen Wu, Yi-an Lin, Ting La, Pan-tong Yao, Yan-ai Mei, Yi Feng* and Lei Xue*, Extremely Low Frequency Electromagnetic Fields Facilitate Vesicle Endocytosis by Increasing Presynaptic Calcium Channel Expression at a Central Synapse, Scientific Reports, [2016], 6(1): 21774.

Jun Guo, Jian-long Ge, Mei Hao, Zhi-cheng Sun, Xin-sheng Wu, Jian-bing Zhu, Wei Wang, Pan-tong Yao, Wei Lin and Lei Xue*, A Three-Pool Model Dissecting Readily Releasable Pool Replenishment at the Calyx of Held, Scientific Reports, [2015], 5(1): 9517.

Jun Guo, Z. C. Sun, P. T. Yao, H. L. Wang and Lei Xue*, A Monte Carlo simulation dissecting quantal release at the calyx of Held, Frontiers in Bioscience (Landmark Edition), [2015], 20: 1079-1091.

Lei Xue, Jiansong Sheng, Xin-Sheng Wu, Wei Wu, Fujun Luo, Wonchul Shin, Hsueh-Cheng Chiang and Ling-Gang Wu, Most vesicles in a central nerve terminal participate in recycling, Journal of Neuroscience, [2013], 33(20): 8820-8826.

Jianhua Xu, Fujun Luo, Zhen Zhang, Lei Xue, Xin-Sheng Wu, Hsueh-Cheng Chiang, Wonchul Shin and Ling-Gang Wu*, SNARE Proteins Synaptobrevin, SNAP-25, and Syntaxin Are Involved in Rapid and Slow Endocytosis at Synapses, Cell Reports, [2013], 3(5): 1414-1421.

Lei Xue, Zhen Zhang, Benjamin D. McNeil, Fujun Luo, Xin-Sheng Wu, Jiansong Sheng, Wonchul Shin and Ling-Gang Wu*, Voltage-dependent calcium channels at the plasma membrane, but not vesicular channels, couple exocytosis to endocytosis, Cell Reports, [2012], 1(6): 632-638.

Jiansong Sheng, Liming He, Hongwei Zheng, Lei Xue, Fujun Luo, Wonchul Shin, Tao Sun, Thomas Kuner, David T. Yue, and Ling-Gang Wu*, Calcium-channel number critically influences synaptic strength and plasticity at the active zone, Nature Neuroscience, [2012], 15(7): 998-1006.

Lei Xue, Benjamin D. McNeil, Xin-Sheng Wu, Fujun Luo, Liming He and Ling-Gang Wu*, A Membrane Pool Retrieved via Endocytosis Overshoot at Nerve Terminals: A Study of Its Retrieval Mechanism and Role, Journal of Neuroscience, [2012], 32(10): 3398-3404.

Lei Xue and Yan-ai Mei*, Synaptic vesicle cycling at the calyx of the Held, Acta Pharmacologica Sinica, [2011], 32(3): 280-287.

Lei Xue and Ling-Gang Wu*, Post-tetanic potentiation is caused by two signaling mechanisms affecting quantal size and quantal content, Journal of Physiology, [2010], 588(24): 4987-4994.

Lei Xue*, Fan Zhang, Xianhua Chen, Junji Lin and Jian Shi, PDZ Protein Mediated Activity-Dependent LTP/LTD Developmental Switch at Rat Retinocollicular Synapses, American Journal of Physiology: Cell Physiology, [2010], 298(6): C1572-C1582.

Liming He, Lei Xue, Jianhua Xu, Benjamin D. McNeil, Li Bai, Ernestina Melicoff, Roberto Adachi and Ling-Gang Wu*, Compound vesicle fusion increases quantal size and potentiates synaptic transmission, Nature, [2009], 459(7243): 93-97.

Xin-Sheng Wu, Benjamin D. McNeil, Jianhua Xu, Junmei Fan, Lei Xue, Ernestina Melicoff, Roberto Adachi, Li Bai and Ling-Gang Wu*, Ca2+ and calmodulin initiate all forms of endocytosis during depolarization at a nerve terminal, Nature Neuroscience, [2009], 12(8): 1003-1010.

Xin-Sheng Wu, Lei Xue, Raja Mohan, Kenneth Paradiso, Kevin D. Gillis and Ling-Gang Wu*, The origin of quantal size variation: vesicular glutamate concentration plays a significant role, Journal of Neuroscience, [2007], 27(11): 3046-3056.

第十二届全国神经科学年会中国天津 2017年10月15日突触传递分会主持
分会报告题目：Endocytosis maintains the release probability during post-tetanic potentiation via clearance of active zone at a central synapse

第十四次中国暨国际生物物理大会中国昆明 2015年11月17日神经环路分会主持
分会报告题目：A Three-Pool Model Dissecting Readily Releasable Pool Replenishment at the Calyx of Held

EMBO膜结构和蛋白重塑研讨会中国西安 2013年5月20日
大会报告题目：Most vesicles in a central nerve terminal participate in recycling

EMBO膜结构和蛋白重塑研讨会中国西安 2013年5月20日
大会报告题目：Most vesicles in a central nerve terminal participate in recycling

第三次国际暨第十二次全国膜生物学学术研讨会中国西安 2012年11月8日
分会报告题目：A Membrane Pool Retrieved via Endocytosis Overshoot at Nerve Terminals

钙离子调控的胞吐/胞吞机制研究及其动力学模型；

钙离子通道及突触传递对突触可塑性的调控；

基于MCELL的精细神经递质释放动力学模型。

Yichen Wu, Qingzhuo Liu, Bin Guo, Fangfei Ye, Jianlong Ge, and Lei Xue, BDNF activates postsynaptic TrkB receptors to induce endocannabinoid release and inhibit presynaptic calcium influx at a calyx-type synapse, Journal of Neuroscience, [2020], 40(42): 8070-8087.

Ying-ying Huang, Yu-qi Wang, Yi-ming Gao, Qing-zhuo Liu, Fang-fei Ye, Bin Guo, Yi-chen Wu and Lei Xue, BDNF and Its Multirole Function in Neurogenesis, Synaptic Transmission and Neurodegenerative Diseases, Nano LIFE, [2020], 10(1-2): 2040007.

Qing-Zhuo Liu, Mei Hao, Zi-Yang Zhou, Jian-Long Ge, Yi-Chen Wu, Ling-Ling Zhao, Xiang Wu, Yi Feng, Hong Gao, Shun Li* and Lei Xue*, Propofol reduces synaptic strength by inhibiting sodium and calcium channels at nerve terminals, Protein & Cell, [2019], 10(9): 688-693.

Bing Jia, Yichen Wu, Dan He, Baihong Guo, and Lei Xue*, Dynamics of transitions from anti-phase to multiple in-phase synchronizations in inhibitory coupled bursting neurons, Nonlinear Dynamics, [2018], 93(3): 1599-1618.

Bing Jia, Huaguang Gu* and Lei Xue, A basic bifurcation structure from bursting to spiking of injured nerve fibers in a two-dimensional parameter space, Cognitive Neurodynamics, [2017], 11(2): 189-200.

Kai Wang, Jun-Mei Lu, Zhen-He Xing, Qian-Ru Zhao, Lin-Qi Hu, Lei Xue, Jie Zhang, and Yan-Ai Mei, Effect of 1.8GHz radiofrequency electromagnetic radiation on novel object associative recognition memory in mice, Scientific Reports, [2017], 7(1): 44521.

Li Li, Hexige Saiyin, Jingmo Xie, Lixiang Ma, Lei Xue, Wei Wang, Weimin Liang, and Qiong Yu, Sevoflurane preconditioning induced endogenous neurogenesis against ischemic brain injury by promoting microglial activation, Oncotarget, [2017], 8(17): 28544-28557.

Jing Cui, Yi Ding, Shu Chen, Xiaoqiang Zhu, Yichen Wu, Mingliang Zhang, Yaxin Zhao, Tong-Ruei R. Li, Ling V. Sun, Shimin Zhao, Yuan Zhuang, Weiping Jia, Lei Xue, Min Han, Tian Xu and Xiaohui Wu, Disruption of Gpr45 causes reduced hypothalamic POMC expression and obesity, Journal of Clinical Investigation, [2016], 126(9): 3192-3206.

Zhi-cheng Sun, Jian-long Ge, Bin Guo, Jun Guo, Mei Hao, Yi-chen Wu, Yi-an Lin, Ting La, Pan-tong Yao, Yan-ai Mei, Yi Feng* and Lei Xue*, Extremely Low Frequency Electromagnetic Fields Facilitate Vesicle Endocytosis by Increasing Presynaptic Calcium Channel Expression at a Central Synapse, Scientific Reports, [2016], 6(1): 21774.

Jun Guo, Jian-long Ge, Mei Hao, Zhi-cheng Sun, Xin-sheng Wu, Jian-bing Zhu, Wei Wang, Pan-tong Yao, Wei Lin and Lei Xue*, A Three-Pool Model Dissecting Readily Releasable Pool Replenishment at the Calyx of Held, Scientific Reports, [2015], 5(1): 9517.

Jun Guo, Z. C. Sun, P. T. Yao, H. L. Wang and Lei Xue*, A Monte Carlo simulation dissecting quantal release at the calyx of Held, Frontiers in Bioscience (Landmark Edition), [2015], 20: 1079-1091.

Lei Xue, Jiansong Sheng, Xin-Sheng Wu, Wei Wu, Fujun Luo, Wonchul Shin, Hsueh-Cheng Chiang and Ling-Gang Wu, Most vesicles in a central nerve terminal participate in recycling, Journal of Neuroscience, [2013], 33(20): 8820-8826.

Jianhua Xu, Fujun Luo, Zhen Zhang, Lei Xue, Xin-Sheng Wu, Hsueh-Cheng Chiang, Wonchul Shin and Ling-Gang Wu*, SNARE Proteins Synaptobrevin, SNAP-25, and Syntaxin Are Involved in Rapid and Slow Endocytosis at Synapses, Cell Reports, [2013], 3(5): 1414-1421.

Lei Xue, Zhen Zhang, Benjamin D. McNeil, Fujun Luo, Xin-Sheng Wu, Jiansong Sheng, Wonchul Shin and Ling-Gang Wu*, Voltage-dependent calcium channels at the plasma membrane, but not vesicular channels, couple exocytosis to endocytosis, Cell Reports, [2012], 1(6): 632-638.

Jiansong Sheng, Liming He, Hongwei Zheng, Lei Xue, Fujun Luo, Wonchul Shin, Tao Sun, Thomas Kuner, David T. Yue, and Ling-Gang Wu*, Calcium-channel number critically influences synaptic strength and plasticity at the active zone, Nature Neuroscience, [2012], 15(7): 998-1006.

Lei Xue, Benjamin D. McNeil, Xin-Sheng Wu, Fujun Luo, Liming He and Ling-Gang Wu*, A Membrane Pool Retrieved via Endocytosis Overshoot at Nerve Terminals: A Study of Its Retrieval Mechanism and Role, Journal of Neuroscience, [2012], 32(10): 3398-3404.

Lei Xue and Yan-ai Mei*, Synaptic vesicle cycling at the calyx of the Held, Acta Pharmacologica Sinica, [2011], 32(3): 280-287.

Lei Xue and Ling-Gang Wu*, Post-tetanic potentiation is caused by two signaling mechanisms affecting quantal size and quantal content, Journal of Physiology, [2010], 588(24): 4987-4994.

Lei Xue*, Fan Zhang, Xianhua Chen, Junji Lin and Jian Shi, PDZ Protein Mediated Activity-Dependent LTP/LTD Developmental Switch at Rat Retinocollicular Synapses, American Journal of Physiology: Cell Physiology, [2010], 298(6): C1572-C1582.

Liming He, Lei Xue, Jianhua Xu, Benjamin D. McNeil, Li Bai, Ernestina Melicoff, Roberto Adachi and Ling-Gang Wu*, Compound vesicle fusion increases quantal size and potentiates synaptic transmission, Nature, [2009], 459(7243): 93-97.

Xin-Sheng Wu, Benjamin D. McNeil, Jianhua Xu, Junmei Fan, Lei Xue, Ernestina Melicoff, Roberto Adachi, Li Bai and Ling-Gang Wu*, Ca2+ and calmodulin initiate all forms of endocytosis during depolarization at a nerve terminal, Nature Neuroscience, [2009], 12(8): 1003-1010.

Xin-Sheng Wu, Lei Xue, Raja Mohan, Kenneth Paradiso, Kevin D. Gillis and Ling-Gang Wu*, The origin of quantal size variation: vesicular glutamate concentration plays a significant role, Journal of Neuroscience, [2007], 27(11): 3046-3056.

第十二届全国神经科学年会中国天津 2017年10月15日突触传递分会主持
分会报告题目：Endocytosis maintains the release probability during post-tetanic potentiation via clearance of active zone at a central synapse

第十四次中国暨国际生物物理大会中国昆明 2015年11月17日神经环路分会主持
分会报告题目：A Three-Pool Model Dissecting Readily Releasable Pool Replenishment at the Calyx of Held

EMBO膜结构和蛋白重塑研讨会中国西安 2013年5月20日
大会报告题目：Most vesicles in a central nerve terminal participate in recycling

EMBO膜结构和蛋白重塑研讨会中国西安 2013年5月20日
大会报告题目：Most vesicles in a central nerve terminal participate in recycling

第三次国际暨第十二次全国膜生物学学术研讨会中国西安 2012年11月8日
分会报告题目：A Membrane Pool Retrieved via Endocytosis Overshoot at Nerve Terminals