| Xue Lei Professor, Doctoral Supervisor Professor and Doctoral Supervisor, Department of Physiology Neurobiology, School of Life Sciences, Fudan University Double-employed Professor, Research Institute of Intelligent Complex Systems, Fudan University |
Research Interests
Calcium-ion regulated mechanisms of endocytosis/exocytosis and their kinetic models.
Regulation of synaptic plasticity by calcium ion channels and synaptic transmission.
Detailed models of neurotransmitter release kinetics based on MCELL.
Education
2000-2005 Ph.D. in Neurobiology, Fudan University (Supervisors: Shou Tiande, Shi Jian)
1996-2000 B.Sc. in Genetics, Fudan University (Supervisor: Qiao Shouyi)
Selected Publications （*：co-first; #, co-corresponding）
1. Wang Y*, Zhang Y*, Hu J, Pan C, Liu Q, Xu W, Xue L#, Hu C#. Cortisol modulates neural activity via a rapid non-genomic effect on Kv2.2 channels in the central nervous system. (2024).Neurobiol. Stress.Volume 28, 100593.
2. Fan WY, Chen YM, Wang YQ, Hu JQ, Feng Y, Cheng Q#, and Xue L#.L-type calcium channel modulates low-intensity pulsed ultrasound-induced neuronal excitation in cultured hippocampal neurons. (2023). Neuroscience Bulletin, in press.
3. Li S*, Gao YM*, Xu Y, Hu JQ, Tang WX, Sun XQ, Xue L#, and Wang WC#. The quercetin-modulated activity-dependent inhibition of endocytosis at a central synapse. (2023). Progress in Biochemistry and Biophysics. 50(6):1391-1402.
4. Wu YC, Liu QZ, Guo B, Ye FF, Ge JL, and Xue L. BDNF activates postsynaptic TrkB receptors to induce endocannabinoid release and inhibit presynaptic calcium influx at a calyx-type synapse. (2020). the Journal of Neuroscience. 40:8070-8087.
5. Huang YY*, Wang YQ*, Gao YM, Liu QZ, Ye FF, Guo B, and Xue L. BDNF and Its Multirole Function in Neurogenesis, Synaptic Transmission and Neurodegenerative Diseases. (2020). Nano LIFE. Vol. 10, Nos. 1 & 2 (2020) 2040007. DOI: 10.1142/S1793984420400073.
6. Liu QZ*, Hao M*, Zhou ZY*, Ge JL, Wu YC, Zhao LL, Wu X, Feng Y, Gao H, Li S#, and Xue L#. Propofol reduces synaptic strength by inhibiting sodium and calcium channels at nerve terminals. (2019). Protein & Cell. 2019 Sep;10(9):688-693.
7. Jia B*, Wu YC, He D, Guo BH, and Xue L. Dynamics of transitions from anti-phase to multiple in-phase synchronizations in inhibitory coupled bursting neurons. (2018). Nonlinear Dynamics. 93: 1599-1618. https://doi.org/10.1007/s11071-018-4279-x.
8. Sun ZC*, Ge JL*, Guo B*, Guo J, Hao M, Wu YC, Lin YA, La T, Yao PT, Mei YA, Feng Y# and Xue L#. Extremely Low Frequency Electromagnetic Fields Facilitate Vesicle Endocytosis by Increasing Presynaptic Calcium Channel Expression at a Central Synapse. (2016). Scientific Reports. Feb 18;6:21774.
9. Guo J*, Ge JL*, Hao M*, Sun ZC*, Wu XS, Zhu JB, Wang W, Yao PT, Lin W and Xue L. A Three-Pool Model Dissecting Readily Releasable Pool Replenishment at the Calyx of Held. (2015). Scientific Reports, 5:9517.
10. Guo J, Sun ZC, Yao PT, Wang HL and Xue L. A Monte Carlo simulation dissecting quantal release at the calyx of Held. (2015). Front Biosci (Landmark Ed) 20:1079–1091.
11. Xue L#*, Sheng J*, Wu XS, Wu W, Luo FJ, Shin Wonchul, Chiang HC, and Wu LG#. Most vesicles in a central nerve terminal participate in recycling. (2013). Journal of Neuroscience，2013 May 15;33(20):8820-6.
12. Xue L*, Zhang Z*, McNeil B, Luo FJ, Wu XS, Sheng JS and Wu LG. Voltage-dependent calcium channels at the plasma membrane, but not vesicular channels, couple exocytosis to endocytosis. (2012). Cell reports, 1 (6) : 632-638.
13. Xue L, McNeil BD, Wu XS, Luo FJ, He L and Wu LG. A Membrane Pool Retrieved via Endocytosis Overshoot at Nerve Terminals: A Study of Its Retrieval Mechanism and Role. (2012). Journal of Neuroscience, 2012 Mar 7; 2(10):3398-404.
14. Xue L and Mei YA. Synaptic vesicle cycling at the calyx of the Held. (2011). Acta Pharmacological Sinica, 2011 Mar;32(3):280-7.
15. Xue L and Wu LG. Post-tetanic potentiation is caused by two signaling mechanisms affecting quantal size and quantal content. (2010). Journal of Physiology (Lond.) 4987–4994.
16. He L*, Xue L*, Xu J, McNeil B, Bai L, Melicoff E, Adachi R and Wu LG#. Compound vesicle fusion increases quantal size and potentiates synaptic transmission. (2009). Nature, 459(7243):93-7.
17. Xue L#*, Zhang F, Chen X, Lin J, Shi J. PDZ Protein Mediated Activity-Dependent LTP/LTD Developmental Switch at Rat Retinocollicular Synapses. (2010). American Journal of Physiology, Cell Physiology, 298(6):C1572-82.
Selected Talks
1. Invited talk, International Academic Symposium on Neuroscience and Brain Disorders, Shenyang, China, Sep. 20, 2023
Report Title: . Cortisol modulates neural activity via a rapid non-genomic effect on Kv2.2 channels in the central nervous system
2. Invited talk, the 8th National Academic Conference of Medical Cell Biology, Shenyang, China, Dec 4, 2021.
Report Title: BDNF activates postsynaptic TrkB receptors to induce endocannabinoid release and inhibit presynaptic calcium influx at a calyx-type synapse
3. Session Chair of the Synaptic Transmission Session at the 12th National Neuroscience Conference, Tianjin, China, October 15, 2017.
Session Report Title: Endocytosis maintains the release probability during post-tetanic potentiation via clearance of active zone at a central synapse.
4. Session Chair of the Neural Circuit Session at the 14th Chinese and International Biophysics Conference, Kunming, China, November 17, 2015.
Session Report Title: A Three-Pool Model Dissecting Readily Releasable Pool Replenishment at the Calyx of Held.
Undergraduate training
1. First Prize in the 2021 National College Student Life Sciences Competition (CULSC), and Grand Prize in Shanghai College Student Life Science Competition.
2. First Prize in the 2022 National College Student Life Sciences Competition (CULSC), and Grand Prize in Shanghai College Student Life Science Competition.
3. First Prize in the 2023 National College Student Life Sciences Competition (CULSC), and Grand Prize in Shanghai College Student Life Science Competition.
