薛磊 (Xue, Lei)

发布者:孙毅 发布时间:2021-03-01 浏览次数:2556

薛磊 教授 博士生导师


复旦大学,生命科学学院

生理与生物物理系,研究员,博士生导师

党派及职务:民革 复旦大学委员会委员

地址: 上海市杨浦区淞沪路2005号复旦大学江湾校区生命科学学院D213室

电话:86-21-31246756 (office)   86-13917771279 (cell)

Email: lxue@fudan.edu.cn

研究方向

主要从事中枢神经系统突触传递机制研究,着重于突触传递的动力学调控,可塑性,分子细胞机制以及相关计算机建模。主要包括:

  1. 钙离子调控的胞吐/胞吞机制研究及其动力学模型;

  2. 钙离子通道及突触传递对突触可塑性的调控;

  3. 基于MCELL的精细神经递质释放动力学模型。

教育经历

  • 复旦大学,2000-2005,神经生物学,硕博连读研究生,导师:寿天德,石建

  • 复旦大学,1996-2000,遗传学,本科生,导师:乔守怡

研究工作经历

  • 复旦大学,2021年至今, 教授,博士生导师

  • 复旦大学,2012-2021年,研究员,博士生导师

  • 美国国立卫生研究院,2010年至2012年,研究科学家

  • 美国国立卫生研究院,2005年至2010年,博士后,导师:Ling-gang Wu

发表论文 Publications

  1. Wu YC, Liu QZ, Guo B, Ye FF, Ge JL, and Xue L. BDNF activates postsynaptic TrkB receptors to induce endocannabinoid release and inhibit presynaptic calcium influx at a calyx-type synapse. (2020). the Journal of Neuroscience. 40:8070-8087.

  2. Huang YY#, Wang YQ#, Gao YM, Liu QZ, Ye FF, Guo B, and Xue L. BDNF and Its Multirole Function in Neurogenesis, Synaptic Transmission and Neurodegenerative Diseases. (2020). Nano LIFE. Vol. 10, Nos. 1 & 2 (2020) 2040007. DOI: 10.1142/S1793984420400073.

  3. Liu QZ#, Hao M#, Zhou ZY#, Ge JL, Wu YC, Zhao LL, Wu X, Feng Y, Gao H, Li S*, and Xue L*. Propofol reduces synaptic strength by inhibiting sodium and calcium channels at nerve terminals. (2019). Protein & Cell. 2019 Sep;10(9):688-693.

  4. Jia B#, Wu YC, He D, Guo BH, and Xue L*. Dynamics of transitions from anti-phase to multiple in-phase synchronizations in inhibitory coupled bursting neurons. (2018). Nonlinear Dynamics. 93: 1599-1618. https://doi.org/10.1007/s11071-018-4279-x.

  5. Jia B#, Gu HG*, and Xue L. A basic bifurcation structure from bursting to spiking of injured nerve fibers in a two-dimensional parameter space. (2017). Cogn Neurodyn. Apr;11(2):189-200.

  6. Wang K, Lu JM, Xing ZH, Zhao QR, Hu LQ, Xue L, Zhang J and Mei YA. Effect of 1.8GHz radiofrequency electromagnetic radiation on novel object associative recognition memory in mice. (2017). Scientific Reports. Mar 17;7:44521.

  7. Li L, Saiyin H, Xie J, Ma L, Xue L, Wang W, Liang W, Yu Q. Sevoflurane preconditioning induced endogenous neurogenesis against ischemic brain injury by promoting microglial activation. (2017). Oncotarget. Apr 25;8(17):28544-28557.

  8. Cui J, Ding Y, Chen S, Zhu X, Wu Y, Zhang M, Zhao Y, Li TR, Sun LV, Zhao S, Zhuang Y, Jia W, Xue L, Han M, Xu T, Wu X. Disruption of Gpr45 causes reduced hypothalamic POMC expression and obesity. (2016). J Clin Invest. 126:3192-3206.

  9. Sun ZC#, Ge JL#, Guo B#, Guo J, Hao M, Wu YC, Lin YA, La T, Yao PT, Mei YA, Feng Y* and Xue L*. Extremely Low Frequency Electromagnetic Fields Facilitate Vesicle Endocytosis by Increasing Presynaptic Calcium Channel Expression at a Central Synapse. (2016). Scientific Reports. Feb 18;6:21774.

  10. Guo J#, Ge JL#, Hao M#, Sun ZC#, Wu XS, Zhu JB, Wang W, Yao PT, Lin W and Xue L*. A Three-Pool Model Dissecting Readily Releasable Pool Replenishment at the Calyx of Held. (2015). Scientific Reports, 5:9517.

  11. Guo J#, Sun ZC, Yao PT, Wang HL and Xue L*. A Monte Carlo simulation dissecting quantal release at the calyx of Held. (2015). Front Biosci (Landmark Ed) 20:1079–1091.

  12. Xue L#*, Sheng J#, Wu XS, Wu W, Luo FJ, Shin Wonchul, Chiang HC, and Wu LG*. Most vesicles in a central nerve terminal participate in recycling. (2013). Journal of Neuroscience2013 May 15;33(20):8820-6.

  13. Xu J#, Luo F, Zhang Z, Xue L, Wu XS, Chiang HC, Shin W and Wu LG*. SNARE Proteins Synaptobrevin, SNAP-25, and Syntaxin Are Involved in Rapid and Slow Endocytosis at Synapses. (2013). Cell reports, May 30;3(5):1414-21.

  14. Xue L#, Zhang Z#, McNeil B, Luo FJ, Wu XS, Sheng JS and Wu LG*. Voltage-dependent calcium channels at the plasma membrane, but not vesicular channels, couple exocytosis to endocytosis. (2012). Cell reports, 1 (6) : 632-638.

  15. Sheng JS#He L, Zheng H, Xue L, Luo FJ, Shin W, Sun T and Wu LG*. Calcium-channel number critically influences synaptic strength and plasticity at the active zone. (2012). Nature Neuroscience, 15(7), 998–1006.

  16. Xue L#, McNeil BD, Wu XS, Luo FJ, He L and Wu LG*. A Membrane Pool Retrieved via Endocytosis Overshoot at Nerve Terminals: A Study of Its Retrieval Mechanism and Role. (2012). Journal of Neuroscience, 2012 Mar 7; 2(10):3398-404.

  17. Xue L# and Mei YA*. Synaptic vesicle cycling at the calyx of the Held. (2011). Acta Pharmacological Sinica, 2011 Mar;32(3):280-7.

  18. Xue L# and Wu LG*. Post-tetanic potentiation is caused by two signaling mechanisms affecting quantal size and quantal content. (2010). Journal of Physiology (Lond.) 4987–4994.

  19. He L#, Xue L#, Xu J, McNeil B, Bai L, Melicoff E, Adachi R and Wu LG*. Compound vesicle fusion increases quantal size and potentiates synaptic transmission. (2009). Nature, 459(7243):93-7.

  20. Xue L#*, Zhang F, Chen X, Lin J, Shi J. PDZ Protein Mediated Activity-Dependent LTP/LTD Developmental Switch at Rat Retinocollicular Synapses. (2010). American Journal of Physiology, Cell Physiology, 298(6):C1572-82.

  21. Wu XS#, McNell B#, Xu J, Fan JM, Xue L, Melicoff E, Adachi R, Bai L and Wu LG*. Ca2+ and calmodulin initiate all forms of endocytosis during depolarization at a nerve terminal. (2009). Nature Neuroscience, 12(8):1003-10.

  22. Wu XS#, Xue L, Mohan R, Paradiso K, Gillis KD, Wu LG*. The origin of quantal size variation: vesicular glutamate concentration plays a significant role. (2007). Journal of Neuroscience, 27(11):3046-56.

会议及报告 Talks

  1. 第十二届全国神经科学年会中国天津 20171015日突触传递分会主持

    分会报告题目:Endocytosis maintains the release probability during post-tetanic potentiation via clearance of active zone at a central synapse

  2. 第十四次中国暨国际生物物理大会中国昆明 20151117日神经环路分会主持

    分会报告题目:A Three-Pool Model Dissecting Readily Releasable Pool Replenishment at the Calyx of Held

  3. EMBO膜结构和蛋白重塑研讨会中国西安 2013520

    大会报告题目:Most vesicles in a central nerve terminal participate in recycling

  4. EMBO膜结构和蛋白重塑研讨会中国西安 2013520

    大会报告题目:Most vesicles in a central nerve terminal participate in recycling

  5. 第三次国际暨第十二次全国膜生物学学术研讨会中国西安 2012118

    分会报告题目:A Membrane Pool Retrieved via Endocytosis Overshoot at Nerve Terminals

学术任职 Academic service

  • 2013中国生物物理学会常务理事

  • 2015中国生物物理学会“膜与细胞生物物理”分会理事

  • 2015上海市非线性科学学会理事

人才计划及获奖 Award

  1. 2012年入选中组部青年千人计划

  2. 2012年入选上海市浦江人才计划

  3. 2014年上海生物物理学会青年科技英才

本科生培养 Undergraduate training

  1. 2015年上海市挑战杯二等奖, 直接指导教师。

  2. 2016年第一届大学生创新创业大赛一等奖,三等奖,优秀组织奖,领队和指导小组负责人。

  3. 2016年浙江生命科学竞赛一等奖,二等奖,领队和直接指导教师。

  4. 2017年第二届大学生创新创业大赛两项一等奖,领队和指导小组负责人。

  5. 2017年全国大学生生命科学竞赛一等奖,二等奖,两项三等奖,指导小组负责人。

  6. 2018年第三届大学生创新创业大赛三项一等奖。

  7. 2019年第四届大学生创新创业大赛特等奖,一等奖。